Importance The SARS-CoV-2 pandemic has infected over a hundred million people worldwide, with almost 2.5 million deaths at the date of this publication. In the United States, Pfizer-BioNTech and Moderna vaccines were first administered to the public starting in December 2020, and no lactating women were included in the initial trials of safety/efficacy. Research on SARS-CoV-2 vaccination in lactating women and the potential transmission of passive immunity to the infant through breast milk is needed to guide patients, clinicians and policy makers during the worldwide effort to curb the spread of this virus.

Objective To determine whether SARS-CoV-2 specific immunoglobins are found in breast milk post-vaccination, and to characterize the time course and types of immunoglobulins present.

Design Prospective cohort study

Setting Providence Portland Medical Center, Oregon, USA

Participants Six lactating women who planned to receive both doses of the Pfizer-BioNTech or Moderna vaccine between December 2020 and January 2021. Breast milk samples were collected pre-vaccination and at 11 additional timepoints, with last sample at 14 days post 2nd dose of vaccine.

Exposure Two doses of Pfizer-BioNTech or Moderna SARS-CoV-2 vaccine.

Main Outcome(s) and Measure(s) Levels of SARS-CoV-2 specific IgA and IgG immunoglobulins in breast milk.

Results In this cohort of 6 lactating women who received 2 doses of SARS-CoV-2 vaccine, we observed significantly elevated levels of SARS-CoV-2 specific IgG and IgA antibodies in breast milk beginning at Day 7 after the initial vaccine dose, with an IgG-dominant response.

Conclusions and Relevance We are the first to show that maternal vaccination results in SARS-CoV-2 specific immunoglobulins in breast milk that may be protective for infants.

 

 

 


References: Jill K. BairdShawn M. JensenWalter J. UrbaBernard A. FoxJason R. Baird. SARS-CoV-2 antibodies detected in human breast milk post-vaccination.

Hrvatsko društvo za perinatalnu medicinu i Hrvatsko društvo za ginekologiju i opstetriciju HLZ-a organiziraju:

XXVIII. SAVJETOVANJE O PERINATALNOM MORTALITETU U REPUBLICI HRVATSKOJ U 2019. GODINI

 

28. siječnja 2021. godine (četvrtak) u 13:00 sati, online

 

Simpozij je bodovan Pravilnikom o trajnoj medicinskoj izobrazbi HLK-a. Kotizacija se ne naplaćuje. Savjetovanje će biti organizirano elektronskim putem, a poveznicu ćete dobiti naknadno. Vezano na bodovanje, svi sudionici dobit će pitanja elektronskim putem, a odgovore je potrebno vratiti mailom na adresu: borisfilipovicgrcic@gmail.com.

Organizacijski odbor:
Dr. sc. Josip Đelmiš, prof. emerit.
Prof. dr. sc. Boris Filipović-Grčić
Prof. dr. sc. Urelija Rodin
Mr. sc. Branimir Peter
Prof. dr. sc. Marko Vulić

 

Program Savjetovanja
13:00-13:10: Josip Đelmiš i Branimir Peter – Pozdrav i uvodna riječ
13:10-14:00: Josip Đelmiš – Perinatalni mortalitet u Republici Hrvatskoj u 2019. godini
14:00-14:30: Urelija Rodin – Uzroci perinatalnih smrti u Hrvatskoj u 2019. godini
14:30-15:00: Boris Filipović-Grčić – Smrtnost novorođenčadi do otpusta iz bolnice u Republici Hrvatskoj u 2019. godini
15:00-15:30: Rasprava
15:30-16:00: Marko Vulić – Patofiziologija preeklampsije
16:00-16:30: Josip Đelmiš – Procjena rizika za preeklampsiju
16:30-17:00: Rasprava

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